What are some examples of human being divorced from nature?

Personally, I think it is better for human beings to transform the world with their own will, not paying attention to nature protection and not following the laws of nature. There are many examples of this situation, such as the current environmental damage and the negative impact of genetically modified food on human health. From the historical examples, there are the disappearance of the ancient capital of Loulan, and the area of Poyang Lake has been sharply reduced due to reclamation around the lake.