How to give full play to the practical application value of genetic testing?

At present, in the eyes of most people, gene decoding is very high-end, as if only high-end talents need it, and it has nothing to do with themselves. Indeed, gene sequencing has just been recognized by everyone, but the role of genetic information has not been recognized by everyone. Even many doctors don't know whether genetic information is reliable and how to use it.

In fact, gene sequencing technology has been very developed. The problem now is not the technology itself, but how to decode the sequenced results and use them in different aspects of life.

Part 1: What does gene sequencing measure?

Genome sequencing is to copy your genetic information from cells by scanning instruments, then read the transformation, then take your gene sequence, and then compare it with the normal genome to see where your differences are. There are usually a lot of different information, which can be detected by sequencing. At present, this instrument is mainly produced by ILLUMINA Company in San Diego, USA, which is a partner of gene decoding.

NIH conducted a clinical trial (ClinSeq) several years ago to discuss how to decode the gene after sequencing and how to apply some results of gene decoding to clinic. Like other clinical studies, NIH recruited healthy adults and provided them with genetic information consultation before and after whole genome sequencing, in order to understand their understanding of the results of gene decoding after sequencing, and how tracking the results of gene decoding affected their psychology, lifestyle and medical choices.

Part II: Similarities and differences of human genes.

The following contents are all from gene consultation of a subject. Here, the name of Wei Zi, a character in China's films, is used instead of the actual name. The confidentiality of genetic information is an important part of Xue Jiajin's decoding service. Because genetic information is highly private, we need to protect each participant and ensure that their genetic information is not abused.

We compare a person's genetic information to an English book, in which one chapter is chromosomes, the paragraphs in each chapter are genes, and the English letters in each paragraph are gene information codes.

If you compare with Wei Zi, you will find that most of your paragraphs are the same. Why? Because you are all human. For example, Wei Zi said in the first paragraph of the third chapter that she should have two legs. The first paragraph of your third chapter should be the same as hers, because you also have two legs. But you may find that in some places, she is A and you are T. This difference is called variation. There may be only one or two different sequences in a natural paragraph, and there may be millions of different sequences in the whole book. These different sequences make you you, Wei Zi is Wei Zi. It is these different sequences that distinguish you from Wei Zi. Wei Zi is characterized by tenderness, while you are generous and charming.

Part III: What is a difference sequence?

Gene decoding expresses some "variations" as "differential sequences". Most of the differential sequences are benign and have no vital influence on the occurrence of diseases. These mutation sequences make each of us different. For example, Ziwei's double eyelids, your single eyelids, Ziwei's high nose and your flat nose, and so on.

Part four: Gene decoding and disease health.

First of all, let's briefly understand the significance of gene decoding through a picture:

The study of gene decoding shows that only a few differential sequences are related to the occurrence of diseases.

1, some differences can explain your health.

For example, hypertension, gene decoding will find the pathogenic genes of these diseases. Perhaps, this result may be what you expected, and it is useless. Because even if you don't do sequencing, you know that you have high blood pressure, and other people in your family know that your risk of high blood pressure will increase. But gene decoding can provide scientific guidance for your treatment of hypertension, because gene decoding can find that your family's hypertension is different from others'. Some people drink chrysanthemum tea to prevent high blood pressure. You may need to use a "silkworm chrysalis pillow". Gene decoding is to let you know your own genetic information, so that you can be more effective and targeted in preventing these diseases.

2. Some differential sequences will provide early warning of disease risk.

For example, if a person carries BRCA 1/2 gene mutation, her risk of breast cancer and ovarian cancer is much higher than others. Therefore, the lifestyle needs to be changed, and the strategy of early cancer screening will be different from others. Furthermore, the real reason can be found through gene decoding, and according to the result of gene decoding, it can even be eradicated through surgery. This also applies to other diseases, such as Alzheimer's disease, cancer risk and so on. Through gene decoding, you can also design personalized prevention or treatment methods.

3. Why are the husband and wife normal and the children sick?

If some mutations show that the father carries a certain disease gene, but it does not cause the father to get sick, it is because he still has a normal gene sequence, which can ensure the health and normality of the father. However, if his wife or girlfriend also carries the disease-causing gene in this place, more than a quarter of their children may get sick. Of course, for most people, this probability is relatively low, and most of them are not serious diseases. But when this happens, they will completely destroy the happiness of a family. This is the scientific basis for gene decoding to launch marriage and love services for everyone. In other words, you don't have any symptoms yourself, but if your other half is also a carrier, the risk of illness for your offspring will increase. Like thalassemia.

4. The mission of gene decoding

There are still some differences that have an unclear impact on our life and health order. I don't know whether this is benign or related to diseases. With the progress of science, the mission of gene decoding is to guide everyone's healthy and happy life to the greatest extent through continuous research, and the tool of this mission is to decode gene information and reveal the influence of each different sequence on human health. It makes our use of human genetic information more accurate, comprehensive and scientific. At the same time, it provides personalized solutions for diseases caused by genetic information changes.

Give yourself a chance to know your genes.

What different sequences do you have?

When will I let you know?

Who has the right to make a decision?

Is it good for you to know? What are the disadvantages?

How to ensure that you can understand these different sequences?

What factors must be considered when making a decision?

These are all things you need to consider, because in the final analysis, it is your genetic information. No one needs to know yourself more than you do.

? The power of understanding:

Knowing the risk of disease, we have more time to change our lifestyle and find a cure. Maybe the illness will be delayed, or even not.

Knowing the cause, we will make a more accurate treatment plan, and perhaps we will not miss the treatment time and waste money;

Yes, we will get rid of the shackles of spirit and don't have to live in unknown fear every day!

Gene profile: Gene Medical Technology (Beijing) Co., Ltd. is a high-tech company dedicated to the interpretation of gene information, which is built by a team of medical experts led by Professor Huang, a famous molecular biologist in China.

Gene decoding, upgrade for genetic testing!