Who knows Xiao Ai's birthday?

In silence ~ ~ ~ ~ ~ ~ ~ ~

I really don't know, just imagine that she is under the same roof with you.

Just send all the information ~

Alias: Hai Bala Ai (Roman pinyin: Ai Bala)

Real name: Miyano Shiho Comics (Volume 18), TV 129, a woman from a dark organization.

Names of Miyano Akemi and Miyano Shiho Source: Miyamura (novelist)

Code-named Shirley, inventor of APTX 4869, No.2 heroine (No.1 supporting actress? )。 Later, he was imprisoned for disobeying the order to murder his sister Miyano Akemi. After taking APTX4869, narrow the scope and escape.

Code name: Shirley (cartoon 18, TV 129, woman from dark organization)

Introduction to sherry:

Origin/Spanish composition/approximate alcohol concentration of grapes/17% ~ 20%' Shirley' is the code name of Miyano Shiho. Miyano Shiho was organized to go abroad for further study at an early age. After returning to China, he worked for the organization and developed poison. I don't need to say the rest. Sherry originated in the Spanish province of Lu Xixi, and is the only place in the world where sherry is produced. Sherry has a slight sweetness and is brewed by palomino, a unique Spanish wine grape variety. In addition, the brewing of sherry is more different from ordinary wine. Shirley's brewing is exposed to the sun in oak barrels. After three months, it will be frozen. Because of the different processing methods, the change of glucose is different from other wines, so Shirley has a special flavor. There are two different types of sherry, and the classification method in the brewing process is' flowering' or' non-flowering'. The so-called flowering means that in the process of brewing, some wines will be covered with a white film. The one with a white film is called' Flower', and this is Fino Shirley. Not very sweet, but light and delicious. In addition,' no flowering' means that there is no white film, which is called Oloroso, which is rich and sweet. It is light, sweet and rich, and the alcohol concentration is not very high (wine is generally 12% ~ 15%).

Nickname: Xiao Ai.

Blood type: AB

Birthday: (unknown)

Origin of the name: "Gray" is cordelia Gray's "Gray": she inherited the will of her partner who committed suicide due to illness and ran a detective agency. The private female detective was only 22 years old. Bright brown hair and green eyes give the impression of a cat, soft outside and rigid inside. Cordelia, who was originally helpless, can only rely on his car "Mini" and the 38-caliber semi-automatic pistol left by his partner after losing his partner to trust him ... There are only two volumes of stories about him, in the special article "Police in gleason" written by writer P.D. James. Although detective work is considered unsuitable for women, her fearless spirit of pursuing the truth of the incident and facing the danger alone is impressive.

"Morning" is the "I" written by V.I. Wozhuoski: a determined, calm and beautiful female detective created by writer Sarah Peggy! She used to be a lawyer and ran a detective agency in Chicago. She used "V.I." instead of "Victoria" because she didn't want to be seen as a woman. Because of her spirit of asking questions, she often jumps everywhere. She is also a karate master, but she is often taken home, her face is black and blue, and she is unconscious. Thanks to my dead father who became a policeman, his marksmanship was also first-class. However, she is not good at cleaning, and her room is often messy. If you don't like it, just tell him that you can't get a boyfriend like this, and promise that you will be punched all over by her.

Constellation: Aquarius

Relatives:

1 Sister: Miyano Akemi.

Comics that have been killed by Gin Volume 2 TV 13 Strange Missing Persons Event TV 128 Dark Organization1000000000 Banditry Event.

2. Father: Miyano Atsushi (name source: animation director of Detective Conan)

He is very famous in the field of science and is called "the mad scientist exiled by the scientific community". He treats people kindly and courteously, and Agasa Hiroshi is still an old acquaintance.

3. Mom: Irene Miyano

He is also a scientist, not very famous, with long brown hair. Glasses with round lenses. British, studied in Japan. Silence. Both parents died in an accident (cartoon 24 TV 176- 178 bid farewell to the dark organization) while studying the "mysterious medicine to bring back the dead" (cartoon 56).

Studying in Class B of Didan Primary School at 1 (in fact, it is a doctoral level in the university) to study in the United States (details are unknown). Comics 18 TV 129 Women from the Dark Organization.

Responder: VEARC- Magician Level 5 10-3 16: 18.

Do you think the best answer is good? At present, there are two comments.

Alias: Hai Bala Ai (Roman pinyin: Ai Bala)

Real name: Miyano Shiho Comics (Volume 18), TV 129, a woman from a dark organization.

Names of Miyano Akemi and Miyano Shiho Source: Miyamura (novelist)

Code-named Shirley, inventor of APTX 4869, No.2 heroine (No.1 supporting actress? )。 Later, he was imprisoned for disobeying the order to murder his sister Miyano Akemi. After taking APTX4869, narrow the scope and escape.

Code name: Shirley (cartoon 18, TV 129, woman from dark organization)

Introduction to sherry:

Origin/Spanish composition/approximate alcohol concentration of grapes/17% ~ 20%' Shirley' is the code name of Miyano Shiho. Miyano Shiho was organized to go abroad for further study at an early age. After returning to China, he worked for the organization and developed poison. I don't need to say the rest. Sherry originated in the Spanish province of Lu Xixi, and is the only place in the world where sherry is produced. Sherry has a slight sweetness and is brewed by palomino, a unique Spanish wine grape variety. In addition, the brewing of sherry is more different from ordinary wine. Shirley's brewing is exposed to the sun in oak barrels. After three months, it will be frozen. Because of the different processing methods, the change of glucose is different from other wines, so Shirley has a special flavor. There are two different types of sherry, and the classification method in the brewing process is' flowering' or' non-flowering'. The so-called flowering means that in the process of brewing, some wines will be covered with a white film. The one with a white film is called' Flower', and this is Fino Shirley. Not very sweet, but light and delicious. In addition,' no flowering' means that there is no white film, which is called Oloroso, which is rich and sweet. It is light, sweet and rich, and the alcohol concentration is not very high (wine is generally 12% ~ 15%).

Nickname: Xiao Ai.

Blood type: AB

Birthday: (unknown)

Origin of the name: "Gray" is cordelia Gray's "Gray": she inherited the will of her partner who committed suicide due to illness and ran a detective agency. The private female detective was only 22 years old. Bright brown hair and green eyes give the impression of a cat, soft outside and rigid inside. Cordelia, who was originally helpless, can only rely on his car "Mini" and the 38-caliber semi-automatic pistol left by his partner after losing his partner to trust him ... There are only two volumes of stories about him, in the special article "Police in gleason" written by writer P.D. James. Although detective work is considered unsuitable for women, her fearless spirit of pursuing the truth of the incident and facing the danger alone is impressive.

"Morning" is the "I" written by V.I. Wozhuoski: a determined, calm and beautiful female detective created by writer Sarah Peggy! She used to be a lawyer and ran a detective agency in Chicago. She used "V.I." instead of "Victoria" because she didn't want to be seen as a woman. Because of her spirit of asking questions, she often jumps everywhere. She is also a karate master, but she is often taken home, her face is black and blue, and she is unconscious. Thanks to my dead father who became a policeman, his marksmanship was also first-class. However, she is not good at cleaning, and her room is often messy. If you don't like it, just tell him that you can't get a boyfriend like this, and promise that you will be punched all over by her.

Constellation: Aquarius

Relatives:

1 Sister: Miyano Akemi.

Comics that have been killed by Gin Volume 2 TV 13 Strange Missing Persons Event TV 128 Dark Organization1000000000 Banditry Event.

2. Father: Miyano Atsushi (name source: animation director of Detective Conan)

He is very famous in the field of science and is called "the mad scientist exiled by the scientific community". He treats people kindly and courteously, and Agasa Hiroshi is still an old acquaintance.

3. Mom: Irene Miyano

He is also a scientist, not very famous, with long brown hair. Glasses with round lenses. British, studied in Japan. Silence. Both parents died in an accident (cartoon 24 TV 176- 178 bid farewell to the dark organization) while studying the "mysterious medicine to bring back the dead" (cartoon 56).

Studying in Class B of Didan Primary School at 1 (actually at doctoral level) to study in the United States (details are unknown). Comics 18 TV 129 Women from the Dark Organization.

Voice: Hayashibara Megumi.

English name: Hayashibara Megumi.

Date of birth:1March 30, 967

Place of birth: Tokyo

Height: 155cm

Weight: 45kg

Company: Art Vision

Debut time: 1986

Favorite food: a lot

Disgusting food: fried pork liver

Favorite animals: dolphins, dogs, sharks.

Interest: collecting phone cards.

Special skills: nurse certificate

Movies and TV series:

Luanma 1/2 Luanma

The Witch of Devil the legend of heroes

"3X3EYES" Peiling Road

"Blue seed" rattan leaves

Nukunuku, the Catwoman of Global Culture

Video girl Julie Watai

Young, a white paper by Youyou.

"DNA2" Saeki Lunzi

Dai Na, Burst Hunter

Tekkaman Blade

The slayer, Lena

Eva Ayanami Rei, Ikari Yui, pen.

"Let's go! The spaceship Yoko Yamamoto, Yutangyuan

A person complains about entertainment

Gundam 0080, Couriss.

Jia Lian, the battle of the sky

New work, big forest, Leo

Detective Conan Haiyuan Ai

Pet elf Musashi

The Lost Universe Kahlan

Space-time Replication of Nazca: A Tour of China in Zhu Tong

Saving marionettes J to X (Eye of the Galaxy) loves beauty.

Super Dimension Fortress Macross

The strongest blood is beautiful.

Queen Emradas

Absolutely invincible ラィジンォ-

Seven songs of Haidi

Beautiful Girl Warrior S (theatrical version) is a famous night bamboo Ji Zi.

"Akihabara Computer Group" Otorii Yan

Cowboy is BOP, Effie

Magic Tutor of Card Catcher KINOMOTO SAKURA (Theater Edition)

Momo, the magic princess

"Magic Battle" Koizumi Akako

The "King of Soul" is afraid of Anna Shana.

Title: "Japan's first seiyuu" and "Comic King"

Debut: Comic Volume 18, animation special "Women from Dark Organizations"

Identity: I was originally a researcher in the mysterious dark organization, and later I was a member of the juvenile detective group (comic 18, TV 129, the woman in the dark organization).

Reasons for decline: She betrayed her by killing her sister Miyano Akemi, and stopped the research on drugs, and was later put into the gas chamber by the organization. I wanted to kill myself by eating APTX4869, but it got smaller and escaped. Comics 18 TV 129 Women from Dark Organizations

Address: After shrinking, I lived next to a new house in Lane 22, Section 2, Jiamihua Road, Agasa Hiroshi (Comics 18, TV 129, a woman of a dark organization). Incidentally, Xinyi's home is No.21of the second section of Mihua Road, and the address of Holmes' home is No.221b Baker Street. what do you think?

Appearance characteristics: very beautiful, short reddish brown blonde hair (cartoon), brown hair (animation), but in the theater version 3 "The Magician at the End of the Century", it is dark orange.

Glorious title: "scientific madman"

Personality: erudite and eloquent (not inferior to Conan, give girls a sigh of relief). Thoughts are unpredictable and unusually calm. The cold appearance (Hirohiko says she is gentle ...) hides mysterious charm. Hazy kindness, cold innocence, some rebellious thoughts (love to play pranks). Don't control your tongue (Conan always gives her three points). She is not very headstrong and seems to have a little feeling about the new one (often joking with Conan). I don't do anything I'm not sure about, and I don't say anything I'm not sure about.

Good at expression: deadpan, or sarcastic (really cool). What Ashala likes most is that the trace of indifference seems to be a smile when he sees what he yearns for.

Favorite color: crimson (cartoon volume 24 TV 176- 178 bid farewell to the dark organization-Gin loves Zuyuan: "Celebrate our reunion with your favorite crimson ...")

Favorite drink: coffee (20 volumes of comics, TV 174, 20 years later, the serial murder in New Forney)

The biggest invention: APTX4869 (a drug that makes new inventions smaller)

APTX is apotoxin, which means "programmed cell death", and the pronunciation of 4869 is "Sherlock" (Sherlock Holmes, a character written by Conan Doyle, needless to introduce, is the figure who has been put on the screen the most in history, synonymous with detective, and the idol of Xinyi! ), so it is called "disability detective" by the organization.

Be good at:

Shot in 1 (in the plot, she shot several times and was shot many times), 28 volumes of comics, TV 176- 178 Goodbye to the dark organization.

2 develop poison.

3 joking. (Xiao Ai makes people laugh when he jokes, which is very powerful ~) There are 30 volumes of comics, and TV 138- 139 finally shows the murder.

Hobbies:

1 likes small animals.

Bear cartoon volume 27TV2/KOOC-0/2-2/KOOC-0/3 Mushroom, Bear and Detective Group, Dog cartoon volume 40 TV233-234 have no evidence of disappearance, and firefly cartoons 52 and 53 have disappeared in Yan Guang.

2 Play computer comics/KOLOC-0/8 TV/KOLOC-0/29 Female comics from dark organizations 34 TV/KOLOC-0/88-/KOLOC-0/93 Resurrection in suspense.

3 read magazines (especially women's clothes) comics 18 TV 129 women in dark organizations.

4. Watch football comics19TV130-131Arena Indiscriminate Threat Comics 48 volumes and 53 volumes.

Favorite movie: "Einstein's Glory and Suffering Years" cartoon 30 volumes TV 138- 139 finally released murder.

Idols: Edison and Einstein.

Favorite team: Osaka team has 48 volumes of comics and 53 volumes of comics.

Bad habits:

1 Anyone who dares to disturb her while studying or looking up information will be finished. Comic 34 volumes TV 188- 193 hanged for life.

It's easy to point a gun at someone. Comics/KOLOC-0/8 TV/KOLOC-0/29 Female Comics from Dark Organizations 34 TV/KOLOC-0/88-/KOLOC-0/93 hanged for life.

Wish: (I guess what she said was a joke) A boring and slightly difficult expression "I want Pagliano's latest handbag" comic 37 volumes.

References:

Sina ~

Respondent: cherry Zongzong-Scholar Level 2 10-3 16:2 1.

/literary novel/8116/414714.html

Defendant: Reno Felix- trainee magician level 2 10-3 16:24.

A little blonde girl with the same symptoms as Conan.

Respondents: QQ 122 188- trainee magician level 2 10-3 16:24.

Name: Haiyuan Ai Dubbing: Hayashibara Megumi

English name: Hayashibara Megumi.

Date of birth:1March 30, 967

Place of birth: Tokyo

Height: 155cm

Weight: 45kg

Company: Art Vision

Debut time: 1986

Favorite food: a lot

Disgusting food: fried pork liver

Favorite animals: dolphins, dogs, sharks.

Interest: collecting phone cards.

Special skills: nurse certificate

Movies and TV series:

Luanma 1/2 Luanma

The Witch of Devil the legend of heroes

"3X3EYES" Peiling Road

"Blue seed" rattan leaves

Nukunuku, the Catwoman of Global Culture

Video girl Julie Watai

Young, a white paper by Youyou.

"DNA2" Saeki Lunzi

Dai Na, Burst Hunter

Tekkaman Blade

The slayer, Lena

Eva Ayanami Rei, Ikari Yui, pen.

"Let's go! The spaceship Yoko Yamamoto, Yutangyuan

A person complains about entertainment

Gundam 0080, Couriss.

Jia Lian, the battle of the sky

New work, big forest, Leo

Detective Conan Haiyuan Ai

Pet elf Musashi

The Lost Universe Kahlan

Space-time Replication of Nazca: A Tour of China in Zhu Tong

Saving marionettes J to X (Eye of the Galaxy) loves beauty.

Super Dimension Fortress Macross

The strongest blood is beautiful.

Queen Emradas

Absolutely invincible ラィジンォ-

Seven songs of Haidi

Beautiful Girl Warrior S (theatrical version) is a famous night bamboo Ji Zi.

"Akihabara Computer Group" Otorii Yan

Cowboy is BOP, Effie

Magic Tutor of Card Catcher KINOMOTO SAKURA (Theater Edition)

Momo, the magic princess

"Magic Battle" Koizumi Akako

The "King of Soul" is afraid of Anna Shana.

Title: "Japan's first seiyuu" and "Comic King"

Debut: Comic Volume 18, animation special "Women from Dark Organizations"

Identity: I was originally a researcher in the mysterious dark organization, and later I was a member of the juvenile detective group (comic 18, TV 129, the woman in the dark organization).

Reasons for decline: She betrayed her by killing her sister Miyano Akemi, and stopped the research on drugs, and was later put into the gas chamber by the organization. I wanted to kill myself by eating APTX4869, but it got smaller and escaped. Comics 18 TV 129 Women from Dark Organizations

Address: After shrinking, I lived next to a new house in Lane 22, Section 2, Jiamihua Road, Agasa Hiroshi (Comics 18, TV 129, a woman of a dark organization). Incidentally, Xinyi's home is No.21of the second section of Mihua Road, and the address of Holmes' home is No.221b Baker Street. what do you think?

Appearance characteristics: very beautiful, short reddish brown blonde hair (cartoon), brown hair (animation), but in the theater version 3 "The Magician at the End of the Century", it is dark orange.

Glorious title: "scientific madman"

Personality: erudite and eloquent (not inferior to Conan, give girls a sigh of relief). Thoughts are unpredictable and unusually calm. The cold appearance (Hirohiko says she is gentle ...) hides mysterious charm. Hazy kindness, cold innocence, some rebellious thoughts (love to play pranks). Don't control your tongue (Conan always gives her three points). She is not very headstrong and seems to have a little feeling about the new one (often joking with Conan). I don't do anything I'm not sure about, and I don't say anything I'm not sure about.

Good at expression: deadpan, or sarcastic (really cool). What Ashala likes most is that the trace of indifference seems to be a smile when he sees what he yearns for.

Favorite color: crimson (cartoon volume 24 TV 176- 178 bid farewell to the dark organization-Gin loves Zuyuan: "Celebrate our reunion with your favorite crimson ...")

Favorite drink: coffee (20 volumes of comics, TV 174, 20 years later, the serial murder in New Forney)

The biggest invention: APTX4869 (a drug that makes new inventions smaller)

APTX is apotoxin, which means "programmed cell death", and the pronunciation of 4869 is "Sherlock" (Sherlock Holmes, a character written by Conan Doyle, needless to introduce, is the figure who has been put on the screen the most in history, synonymous with detective, and the idol of Xinyi! ), so it is called "disability detective" by the organization.

Responder: Shadow-Magic Apprentice Level 1 10-3 16:40.

I like Haiyuan Ai very much.

Responder: cajanus cajan-apprentice magician level 2 10-3 17:06.

I like her very much.

Responder: Shelley Ai- Magic Apprentice Level 1 10-3 17:23

In fact, I know nothing except that she is Shirley.

Answer: Blue ☆ Mind Magic Apprentice Level 1 10-4 12:40.

Alias: Hai Bala Ai (Roman pinyin: Ai Bala)

Real name: Miyano Shiho (file. 176 to students (students) comics 18 TV 129 women from dark organizations).

Names of Miyano Akemi and Miyano Shiho Source: Miyamura (novelist)

Code name: Shirley (FILE. 178) Member of the mysterious organization: Code name: Shirley (コードネームシェリー) Comic 65438+.

Introduction to sherry:

Origin/Spanish composition/approximate alcohol concentration of grapes/17% ~ 20%' Shirley' is the code name of Miyano Shiho. Miyano Shiho was organized to go abroad for further study at an early age. After returning to China, he worked for the organization and developed poison. I don't need to say the rest. Sherry originated in the Spanish province of Lu Xixi, and is the only place in the world where sherry is produced. Sherry has a slight sweetness and is brewed by palomino, a unique Spanish wine grape variety. In addition, the brewing of sherry is more different from ordinary wine. Shirley's brewing is exposed to the sun in oak barrels. After three months, it will be frozen. Because of the different processing methods, the change of glucose is different from other wines, so Shirley has a special flavor. There are two different types of sherry, and the classification method in the brewing process is' flowering' or' non-flowering'. The so-called flowering means that in the process of brewing, some wines will be covered with a white film. The one with a white film is called' Flower', and this is Fino Shirley. Not very sweet, but light and delicious. In addition,' no flowering' means that there is no white film, which is called Oloroso, which is rich and sweet. It is light, sweet and rich, and the alcohol concentration is not very high (wine is generally 12% ~ 15%).

Nickname: Xiao Ai.

Seiyuu: Hayashibara Megumi (also voiced Koizumi Akako in the movie)

Birthday: 65438+February 1.

Blood type: AB

Origin of the name: Agatha Hong and herself took it (FILE. 178, member of the mysterious organization: code Shirley (コードネームシイー) cartoon.

"Grey" is cordelia? Gray: She inherited the will of her partner who committed suicide due to illness and ran a detective agency. The private female detective was only 22 years old. Bright brown hair and green eyes give the impression of a cat, soft outside and rigid inside. Cordelia, who was originally helpless, can only rely on his car "Mini" and the 38-caliber semi-automatic pistol left by his partner after losing his partner to trust him ... There are only two volumes of stories about him, written by writer P.D. James in the special article "Police in gleason". Although detective work is considered unsuitable for women, her fearless spirit of pursuing the truth of the incident and facing the danger alone is impressive.

Sadness is V.I. Wachowski's "I": writer Sarah? The determined, calm and beautiful female detective created by Page! She used to be a lawyer and ran a detective agency in Chicago. She used "V.I." instead of "Victoria" because she didn't want to be seen as a woman. Because of her spirit of asking questions, she often jumps everywhere. She is also a karate master, but she is often taken home, her face is black and blue, and she is unconscious. Thanks to my dead father who became a policeman, his marksmanship was also first-class. However, she is not good at cleaning, and her room is often messy. If you don't like it, just tell him that you can't get a boyfriend like this, and promise that you will be punched all over by her.

Age: temporary 7 years old, actual 18 years old (file. 19056000 hostages (56000 people)? Brvbar) Comics 19 TV 130- 13 1 Indiscriminate coercion in the arena-sad for Conan: "In fact, I am just like you, only 18 years old." )

First appearance: FILE. 176 to student (student は) comics 18 TV 129 women from dark organizations.

Identity: I was originally a researcher of the mysterious dark organization, and later I was a member of the juvenile detective group (FILE. 176 transfer student (student は), comic 18, TV 129, woman of the dark organization).

Reasons for decline: She betrayed her by killing her sister Miyano Akemi, and stopped the research on drugs, and was later put into the gas chamber by the organization. I wanted to kill myself by eating APTX4869, but like the new one, I became a child, able to get rid of handcuffs and escape from the garbage passage. Because I knew that Xinyi was getting smaller, I wanted to ask him for help. Finally, I fell down at the door of the new house and was lifted up by the doctor. Because of the lack of information, it is impossible to make an antidote, but it is a hope anyway. After all, she developed APTX4869. (FILE. 176 to students (students) comics 18 TV 129 women in dark organizations)

Relatives:

1 Sister: Miyano Akemi.

Has been killed by Gin (Comic Book II TV 13 Strange Missing Event TV 128 Dark Group100000000000 Yuan Robbery Event).

Father: Miyano Atsushi (name source: Aono Atsushi, animation director of Detective Conan)

He is very famous in the field of science and is called "the mad scientist exiled by the scientific community". He treats people kindly and courteously, and Agasa Hiroshi is still an old acquaintance. (Comics 39 volumes TV329-330 Friendship that money can't buy)

3 Mom: Irene Miyano

He is also a scientist, not very famous, with long brown hair. Glasses with round lenses. An Englishman, studying in Japan, is taciturn. In document 425, she can see her love for her daughter. It is called the angel of hell by the organization (the angel who fell into hell)

Both parents study "mysterious drugs to bring back the dead". All died in an accident (FILE.242 White World Comics Volume 37 TV 176- 178 Contact with dark organizations)

Study: Class B of Didan Primary School in 1 (there is no way to reduce it) studied in the United States (details are unknown) (Comics 18, TV 129, Women in Dark Organizations)

Address: After the reduction, I will live next to a new home in Lane 22, the second section of Mihua Road, Agasa Hiroshi. The new home (No.21No.2, the second section of Mihua Road) → Sherlock Holmes Address: No.221B(file. 176) comics.

Hair color:

Short brown-red wavy blonde comics 28 volumes

Television with Brown Hair Theater Edition 4: Assassin among Primary School Students 5: Countdown to Heaven 6: Dead Man in Baker Street 7: Crossroads of Labyrinth.

Deep orange theater version 3 "Magician at the end of the century"

Personality: erudite and eloquent (not inferior to Conan, give girls a sigh of relief). Thoughts are unpredictable and unusually calm. The cold appearance (Hirohiko says she is gentle ...) hides mysterious charm. Hazy kindness, cold innocence, some rebellious thoughts (love to play pranks). Don't control your tongue (Conan always gives her three points). She is not very headstrong and seems to have a little feeling about the new one (often joking with Conan). I don't do anything I'm not sure about, and I don't say anything I'm not sure about.

Good at expression: deadpan, or sarcastic (really cool). What Ashala likes most is that the trace of indifference seems to be a smile when he sees what he yearns for.

Favorite color: crimson (FILE.242 White World Comics Volume 24 TV 176- 178 Farewell to dark organizations-Gin to Ashihara: "Celebrate our reunion with your favorite crimson ...")

Favorite drink: coffee (Comic 23, TV 174, serial murder of new Buddha in 20 years)

Glorious title: "scientific madman"

The biggest invention: APOPTOXIN4869(アポトキシン4869).

APTX is apotoxin, which means "programmed cells die by themselves", and the pronunciation of 4869 is "Sherlock" (Sherlock? Holmes, Conan? Doyle's characters, needless to introduce, are the characters who have been put on the screen the most in history, and they are also synonymous with Xinyi's detectives and idols! ), so it is called "disability detective" by the organization.

"APOTOXIN" is a combination of apoptosis and toxin. It is a drug that unconditionally promotes the self-death of human cells, and the specific situation is unknown.

In this paper, we especially investigate what this fascinating drug is, and consider its doubts and problems comprehensively.

The concept of APOTORCEISE is not a long time ago. Traditionally, cell death is considered as "cell necrosis", while self-death is only a form of necrosis.

Cell necrosis is a word that means that cells die due to some external factors. For example, cuts, burns, etc. , hinder the cell function, damage the cell membrane, resulting in the loss of internal cytoplasm, ions and so on to the outside of the cell. In other words, some destructive external force leads to "accidental death" of cells, causing edema, fever and even purulent bleeding. This obvious phenomenon can be directly observed, so it has been known for a long time, and it has long been thought that this is the way of cell death.

In contrast, cell death is a phenomenon that cells are automatically destroyed and absorbed by surrounding cells. For example, when a tadpole turns into a frog, its tail disappears. In the early stage of finger formation, the pu-like part between fingers disappeared, and this part of cells died, forming fingers. Or it is not such a process of life transformation and occurrence, resulting in abnormal self-death of cells, excessive cell division, self-death of cells whose lives have expired, and so on. Through radiation or drugs, this is a phenomenon of cell death caused by daily life.

Unlike cell necrosis, which is greatly influenced by surrounding cells, self-death is very "intelligent". Careful analysis of DNA in dead nuclei can confirm very small fragment changes, which are called "coagulative necrosis". This part of debris is quickly absorbed by the surrounding cells, and the form after death becomes the nutrient of the surrounding cells.

The interesting thing about cell self-death is that it determines the "location" of cell self-death. For example, in the example of finger formation mentioned above, the message of "there are cells that you don't need" is identified around dead cells-although this process has not been explained clearly, it can be seen from the process of some cells disappearing and finger formation that the message of "don't want those cells" is transmitted through the cortex.

If it becomes irreversible through radiation and other processes, cells will be judged as abnormal cells and cannot divide and proliferate. After the process of making this judgment, the "death gene" on the DNA in the cell will be activated, thus inducing the self-death process of the cell. At present, there are dozens of "death genes" that can be analyzed, and research is being carried out to analyze their functions.

To sum up, self-death is a phenomenon in which cells choose to die according to their own judgment in order to remove unnecessary cells that proliferate excessively, or to make unexpected somatic cells with sudden mutation life-threatening. Therefore, it has become "self-destruction."

In the current research of anticancer drugs, drugs that cause cell death are being studied. Cancer is a disease caused by the continuous proliferation of cells that should be destroyed by self-death, so it can be cured by promoting the normal process of self-death. The anticancer drugs used now are all drugs that induce cancer cells to die on their own, but the side effects are the same.