Cancer prevention and fortune-telling genetic testing are known in advance.

The indestructible little creature water bear worm finds its way out from genes. What effect does the clinical application of gene technology have on genes? A few days ago, Vivian, a famous astrological numerology expert in Taiwan Province Province, died of breast cancer at the age of 43. The news shocked all walks of life. After the major media reports, it also aroused women's concern about * * * and ovarian health. In addition to numerology divination, it is now possible to know whether the family or itself is a high-risk group of breast cancer and ovarian cancer through more scientific BRCA gene detection.

BRCA gene mutation, breast cancer and ovarian cancer may occur in advance. Normal human cells will go through an induction period and incubation period, and this canceration time mostly takes more than several decades. The probability of normal women suffering from breast cancer before the age of 40 is about 5%, but the average age of patients with familial breast cancer with BRCA gene mutation is 10 years earlier than that of normal women, and most of them are found to have breast cancer before the age of 40. Since 1990 discovered BRCA 1 and BRCA2 tumor suppressor genes, many studies have pointed out that the mutation of these two genes is closely related to the occurrence of hereditary breast cancer and ovarian cancer. Studies have pointed out that women with BRCA 1 mutation gene have a lifetime risk of breast cancer of 80% and ovarian cancer of 50%, of which the risk of breast cancer before 70 years old is 87%, which is 1 1 times that of normal people, and the risk of ovarian cancer before 70 years old is as high as 44-50%. If you have the BRCA2 mutant gene, the risk of breast cancer before the age of 70 is 80%. Men with BRCA2 mutation may also suffer from male breast cancer, and the risk of prostate cancer and pancreatic cancer will also increase.

The role of BRCA gene in human body The BRCA 1 gene is located on chromosome 17, while the BRCA2 gene is located on chromosome 13. Normal BRCA gene products will participate in the repair mechanism of DNA damage and repair broken double-stranded DNA through homologous recombination, so BRCA gene belongs to a tumor suppressor gene. Once the gene mutates, the gene product can not participate in the normal repair function. When the DNA damage accumulates to a certain extent, the cell will become cancerous.

Scientific fortune-telling -BRCA genetic testing At present, 1 in every 8 women will develop breast cancer at some stage. Many women are very worried about their risk of breast cancer. When people go to see a doctor, in addition to asking about family history, age, abnormal medical history, age of menarche and age of first pregnancy, BRCA gene testing is one of the most direct methods to assess the risk of breast cancer. Through genetic testing, we can know whether the subjects have BRCA gene mutation as soon as possible, and then know whether they belong to high-risk groups, so as to make preventive follow-up or treatment as soon as possible. Of course, for members with a family history of breast cancer/ovarian cancer, it is necessary to find out whether their BRCA mutation or high-risk family members with BRCA gene mutation are carriers, so as to take preventive measures as soon as possible. Angelina Jolie, an American Hollywood movie star, is a prominent example. In contrast, the risk of breast cancer in men with BRCA 1 or BRCA2 mutation is much lower than that in women, but the risk of prostate cancer and pancreatic cancer is still higher than that in normal people. In addition, men with BRCA2 mutation may also suffer from male breast cancer, so they should seek appropriate advice and receive careful follow-up observation.

Gene detection should attach importance to the detection of gene mutation in BRCA 1/BRCA2 database, which can be said to be one of the most important breakthroughs of scientists in genetic diseases in recent ten years. The mutation sites of BRCA 1/BRCA2 in Europe and America are different from those in the East, so it is relatively important to check whether the company has a large Chinese database. Furthermore, the mutation sites may be all over the BRCA 1/BRCA2 gene, so the whole sequence analysis is needed instead of specific single point analysis. If you want to detect BRCA gene, it is best to choose a detection unit that can analyze the complete sequence of BRCA 1/BRCA2 and compare it with the Asian Chinese gene database. In addition, we should also pay attention to whether the detection system can detect BRCA gene mutation caused by DNA fragment deletion/duplication.

Subject: BRCA, breast cancer, ovarian cancer, gene detection, gene technology, cancer treatment, preventive medicine.