Brief introduction of Zhigancao decoction

Directory 1 Pinyin 2 English Reference 3 Overview 4 Treatise on Febrile Diseases 4. 1 Alias 4.2 Composition 4.3 Usage 4.4 Efficacy and Indication 4.5 Prescription 4.6 Clinical Application 4.6. 1 Addition and subtraction 4.7 Modern indications 4.7. 1 Hyperthyroidism 4.7.2 Coronary Heart Disease 4.7.3 Viral Myocarditis 4.7.4 Arrhythmia 4.8 Pharmacological Effects of Zhigancao Decoction 4.8.65438+ Effects of Endocrine System 4.8.4 Effects on Hematopoiety and Cell Function 4.8.5 Antioxidant and Anti-aging Effects 4.9 Melody 4. 10 Origin 5 "Rhinoceros and Candle Miscellaneous Diseases" Prescription 5.2 Composition 5.3 Indications 5.4 Notes 5.5 Source 6 Reference Attachment: Roasted Glycyrrhiza Decoction in Ancient Books 1 Pinyin ZH Gān c m 4 o tāng

2 English reference roasted licorice soup [Chinese medicine terminology Committee. Terminology of Traditional Chinese Medicine (2004)]

Jianzi decoction [Xiangya Medical Dictionary]

There are about two prescriptions of the same name in Zhigancao Decoction, among which the prescriptions recorded in Treatise on Febrile Diseases are commonly used, including Zhigancao 12g, Ginger 9g, Ramulus Cinnamomi 9g, Ginseng 6g, Radix Rehmanniae 30g, Colla Corii Asini 6g, Ophiopogon japonicus 10g, Fructus Cannabis 10g and Jujube/kloc. Has the effects of invigorating qi, nourishing yin, activating yang and restoring pulse. Indications: heart pulse dystrophy caused by qi deficiency and blood weakness. This prescription is yin-yang and qi-blood tonic. It is often used in patients with functional arrhythmia, extrasystole, coronary heart disease, rheumatic heart disease, viral myocarditis, hyperthyroidism and so on. It is characterized by palpitation, shortness of breath and rapid pulse, and belongs to yin-blood deficiency and yang-qi weakness.

Clinical Report of Zhigancao Decoction in Treatise on Febrile Diseases: Zhigancao Decoction is effective in treating sick sinus syndrome 1 1 case, with 4 cases being effective 1 1 case and the effective rate 100%, which shows that Zhigancao Decoction has therapeutic effect on arrhythmia and hyperthyroidism. The effect of this recipe on neuroendocrine function and cell function can not be ignored, and its function of "nourishing yin and nourishing blood" lies in this. Its effect of "benefiting qi and nourishing yin" may be related to its regulation of nervous and endocrine functions, immune promotion and regulation, and its positive influence on cardiovascular and hemorheology. [ 1]

4. 1 alias fried licorice fumai decoction (treatise on febrile diseases).

4.2 Four ounces of licorice (stir-fried), three ounces of ginger (cut), two ounces of ginseng, one catty of rehmannia glutinosa, three ounces of cassia twig (peeled), two ounces of donkey-hide gelatin, half a liter of Ophiopogon japonicus (pitted), half a liter of hemp seed and thirty pieces of jujube (broken) [2].

Radix Glycyrrhizae Preparata 12g, Rhizoma Zingiberis Recens 9g, Ramulus Cinnamomi 9g, Ginseng 6g, Radix Rehmanniae 30g, Colla Corii Asini 6g, Radix Ophiopogonis 10g, Fructus Cannabis 10g, and Fructus Jujubae 10 [3].

Licorice 12g (stir-fried) ginger 9g (sliced) ginseng 6g Radix Rehmanniae 30g Ramulus Cinnamomi 9g (peeled) Ejiao 6g Radix Ophiopogonis 10g (pitted) hemp 10g Jujube 30 pieces (crushed).

Licorice (fried) 12g, ginger (cut) 9g, cassia twig (peeled) 9g, ginseng 6g, Radix Rehmanniae 50g, Colla Corii Asini 6g, Ophiopogon japonicus (pitted) 10g, Fructus Cannabis 10g, and jujube 10 [4].

4.3 When using, use seven liters of sake and eight liters of water. Cook eight flavors first, take three liters, then take me out and melt the donkey-hide gelatin for eating. Three times a day, one liter each time, with warm clothes.

Add sake 10ml and decoct in water. [3]

Nine kinds of drugs were applied, sake 10 ml and water 800 ml. First, boil the eight herbs, take 300 ml, and melt the inner glue. 100 ml warm clothing, three times a day.

Seven liters of sake and eight liters of water are served. Boil eight flavors first, take three liters, and melt the inner glue. Take a warming suit three times a day. [4]

4.4 Efficacy and indications [3]

Zhigancao decoction has the effects of benefiting qi, nourishing yin, activating yang and restoring pulse. Indications:

1. Qi deficiency and blood deficiency, heart and pulse dystrophy. Symptoms include pulse knot formation, palpitation, qi deficiency, pale tongue with little coating, or emaciation.

2. Exhaustive lung failure. Symptoms include dry cough without phlegm, or cough with saliva foam, small amount, thin and short breath, insomnia, spontaneous sweating and night sweats, dry throat and tongue, dry stool and weak pulse.

4.5 Prescription Jiezhi Gancao Decoction is mainly used to treat heart and pulse dystrophy caused by qi deficiency and blood deficiency, and the treatment should be mainly based on invigorating qi and nourishing yin, dredging yang and restoring pulse. In the prescription, Radix Glycyrrhizae Preparata and Radix Rehmanniae are reused, benefiting qi, nourishing yin and nourishing blood as monarch drugs. Ginseng and jujube are beneficial to the heart and spleen; Colla Corii Asini, Ophiopogon japonicus and Fructus Cannabis nourish the heart and blood, all of which are minister drugs. Cinnamomum cassia twig, ginger and sake are all adjuvants. The combination of various medicines is warm but not dry, nourishing but not greasy, and plays the role of benefiting qi and nourishing blood, nourishing yin and restoring pulse. [3]

Zhigancao decoction was first used to treat typhoid pulse palpitation caused by deficiency of yin and blood and weakness of yang. Yin blood is insufficient and blood vessels cannot be filled; If the yang is weak and can't stimulate blood vessels, the pulse will be blocked, and the pulse will be knotted and the heart will tremble. It is advisable to nourish the heart yin, do practical work, benefit the heart qi, warm the heart yang, and stop the palpitation with the pulse. Rehmannia glutinosa is used to nourish yin and blood in the prescription. The compatibility of Radix Glycyrrhizae Preparata, Radix Ginseng and Fructus Jujubae is beneficial to heart-qi and spleen-qi, which are the biochemical sources of qi and blood. Ejiao, Ophiopogon japonicus and Sagittarius nourish the heart and yin, nourish the heart and blood, and fill the blood vessels. Ramulus Cinnamomi, Rhizoma Zingiberis Recens, warming heart yang, promoting blood circulation and removing blood stasis are supplemented. The combination of all kinds of medicines can make yin and blood fill, blood vessels fill, Yang Qi fill, and heart and pulse flow unobstructed, thus forming the tonification of yin and yang and qi and blood. In this way, qi and blood are sufficient, yin and yang are harmonious, and palpitations determine the pulse, so this prescription is also called "Fumai Decoction". In usage, add wine to decoct and take, so as to clear the wine and make it spicy, which can warm blood vessels and exercise medicine. [4]

4.6 Clinical Application of Zhigancao Decoction; Zhigancao Decoction is a medicine for nourishing yin and yang and qi and blood. Clinically, pulse knot, palpitation, qi deficiency, pale tongue with little coating are the main points of syndrome differentiation and treatment. [3]

4.6. 1 The modified formula can add Semen Ziziphi Spinosae and Semen Platycladi to enhance the power of nourishing the heart and calming the nerves, or add dragon teeth and magnets to calm the nerves; Those with insufficient heart spirit should reuse roasted licorice and ginseng; Those who prefer yin deficiency and blood deficiency reuse Radix Rehmanniae and Radix Ophiopogonis; For patients with heart yang deficiency, cassia twig is cinnamon, and aconite root is added to enhance the power of warming heart yang; For those with yin deficiency and internal heat, the easy ginseng is Radix Adenophorae. After deducting cinnamon, ginger, jujube and alcohol, Anemarrhena asphodeloides and Cortex Phellodendri are added as appropriate, and the effect of nourishing yin liquid on reducing deficiency fire is stronger. [3]

4.7 Modern indications [5]

Zhigancao decoction has a good effect on functional arrhythmia and extra-phase contraction. Used for coronary heart disease, rheumatic heart disease, viral myocarditis, hyperthyroidism, etc. With palpitation, shortness of breath and pulse knot, it can be modified for fatigue and dry cough caused by both qi and yin injuries.

4.7. 1 hyperthyroidism The most common cause of hyperthyroidism is diffuse toxic goiter (Graves' disease). At present, it is recognized that the occurrence of this disease is related to autoimmunity, but the mechanism of immune system dysfunction is not clear, and there are mainly the following theories: ① immune tolerance system disorder. Eliminate the functional loss of reactive T cells in thymus or peripheral links, leading to such reactive T cells attacking thyroid tissue. ② The abnormal expression of immune-related proteins on the surface of thyroid cells makes them antigen presenting cells, which induces and aggravates the autoimmune reaction against thyroid. ③ The functional defect of specific inhibitory T cells determined by genetic background leads to the enhancement of helper T cells and B cells. At the same time, environmental factors and infection factors also participated in the occurrence of the disease. The main pathological changes were diffuse goiter, follicular epithelial cell proliferation and lymphocyte infiltration. The main clinical manifestations are hypermetabolic syndrome such as overeating, hunger and fatigue; Mental and nervous system changes, such as anxiety, irritability, insomnia and hyperactivity; Cardiovascular system may have palpitation, shortness of breath, tachycardia, arrhythmia, etc. And digestive, muscular, skeletal, hematopoietic and reproductive system dysfunction. The main signs are diffuse goiter and exophthalmos.

4.7.2 Coronary Heart Disease Coronary heart disease is called coronary atherosclerotic heart disease. It is common in middle-aged and elderly patients with hyperlipidemia, hypertension, smoking and diabetes who have increased blood total cholesterol, triglyceride and low density lipoprotein cholesterol. In the case of long-term hyperlipidemia, low-density lipoprotein and cholesterol cause functional damage to the intima of arteries, change the surface characteristics of vascular endothelial cells and white blood cells, and increase the expression of adhesion factors. The number of monocytes adhering to endothelial cells increased, and they migrated to human intima to become macrophages. Oxidized low-density lipoprotein was swallowed by scavenger receptors, forming lipid stripes of atherosclerotic lesions. At the same time, macrophages can oxidize low-density lipoprotein, form peroxides and superoxide anions, and synthesize and secrete six cytokines such as platelet-derived growth factor (PDEF), fibroblast growth factor (FGF) and transforming growth factor β(TGFβ). PDGF and FGF *** Smooth muscle cells and fibroblasts proliferate and migrate to intima, and also * * * new connective tissue. PDGF and PDEFβ not only make smooth muscle cells migrate to the fat zone rich in macrophages and transform into foam cells, but also promote the fat zone to evolve into fibrous fatty lesions and develop into fibrous plaques. In addition, hemodynamic changes such as hypertension will interrupt the continuity of endothelial cells in the intima of arteries and expose the subcutaneous tissue. At this time, platelet activating factor activates platelets in blood, making them adhere to the intima and form adhesive thrombus; Platelets release many cytokines, including macrophages, which enter the arterial wall and promote arteriosclerosis; At the same time, T lymphocytes were found in various stages of arteriosclerosis lesions, suggesting that the development of lesions may be related to immune or autoimmune reactions. The main pathological changes are myocardial ischemia, hypoxia or necrosis caused by coronary artery stenosis or spasm, and a series of symptoms appear clinically, such as myocardial ischemia, angina pectoris, myocardial infarction, ischemic heart disease, sudden death, and the most common is angina pectoris.

4.7.3 See Danggui Huang Liu Decoction for the etiology and pathogenesis of viral myocarditis. Rheumatic heart disease is a late complication after angina pectoris caused by group B hemolytic streptococcus infection. M protein and its related proteins: N- acetylglucosamine and rhamnose in the outer protein of cell wall of this strain have common antigenicity with plasma proteins of human myocardium, cell membrane and heart valve, and have autoimmune reaction with human myocardial tissue. First of all, these streptococcus antigens and autoantigens simulated by streptococcus antibodies form immune complexes, which are deposited in myocardium and heart valves, activating complement components and producing inflammatory lesions. Secondly, the cellular immune response is abnormal: ① the proliferation of peripheral lymphocytes to streptococcus antigen is enhanced, and children's T lymphocytes have cytotoxic effect on myocardial cells; ② The inhibition test of peripheral blood on leukocyte migration induced by streptococcus antigen was enhanced, the proliferation reaction of lymphocytes was reduced, and the function of NK cells was enhanced; ③ The immune response of tonsil monocytes to streptococcus antigen was abnormal. Third, other toxins of bacteria and personal genetic background can also cause inflammation of myocardium and valves. The main pathological changes are exudation, hyperplasia and sclerosis. The main clinical manifestations are fever, dark heart sounds, arrhythmia, and severe heart failure. When the valve is diseased, abnormal murmurs can be heard in the valve area; There may be signs of pericardial effusion when pericarditis occurs.

4.7.4 Arrhythmia Arrhythmia includes: ① abnormal impulse formation, abnormal excitation of autonomic myocardial cells in sinoatrial node, internodal bundle, atrioventricular node, atrioventricular bundle and His bundle-Purkinje system, including sinus arrhythmia and ectopic arrhythmia; ② Abnormal impulse conduction, including physiological, pathological and atrioventricular conduction pathways. These two abnormalities will lead to various forms of arrhythmia. There are many primary diseases that cause arrhythmia, such as myocarditis and coronary heart disease, which are mainly caused by electrophysiological abnormalities such as excitability, conductivity and autonomy of myocardial cells. There are many kinds of arrhythmia, which must be diagnosed by ECG. The main clinical manifestations are palpitation and precordial discomfort, which can cause syncope and sudden death in severe cases.

4.8 Pharmacological Effects of Zhigancao Decoction [6]

4.8. Effect of1on immune function Animal experiments show that Radix Rehmanniae can resist the decrease of plasma corticosterone concentration caused by continuous administration of dexamethasone and prevent adrenal cortex atrophy. Its water extract can promote the biosynthesis of DNA and protein in ConA-activated lymphocytes, enhance the production of IL-2, significantly increase T lymphocytes in peripheral blood and enhance the phagocytic function of reticuloendothelial system. Ginseng is a ministerial medicine, which has a wide range of effects on cellular immunity and humoral immunity. Ginsenoside and ginseng polysaccharide are active components of ginseng for regulating immune function. Ginseng can not only improve the immune function of normal animals, but also improve the immune function of animals with low immune function. Ginseng flower saponin can increase the concentration of specific antibody, raise the levels of serum IgG, IgA and IgM, promote phagocytosis of reticuloendothelial system, and promote lymphatic transformation of T and B lymphocytes caused by mitogen. Ginsenosides can increase the proliferation of ConA, promote the production of IL-2 and improve the activity of spleen NK cells. Ginseng polysaccharide can promote phagocytosis of reticuloendothelial system, induce THF and anti-complement activity. Glycyrrhiza uralensis Fisch can not only induce interferon and enhance NK cell activity, but also inhibit mast cell degranulation, which has anti-allergic effect. Glycyrrhizic acid can also increase the weight of spleen and thymus, enhance the activity of reticuloendothelial system, significantly increase antibodies in vivo and activate lymphocyte proliferation; Licorice Lx can reduce the amount of antigen, play an immunosuppressive role and inhibit penicillin anaphylactic shock; Glycyrrhiza polysaccharide can improve the phagocytosis of reticuloendothelial system and monocytes; Glycyrrhizin can inhibit the release of histamine from mast cells and enhance the secretion of IL-2 from lymphocytes induced by ConA. Glycyrrhetinic acid can increase lymphocyte ratio; Diammonium glycyrrhizinate can increase the level of interferon α in serum; β -glycyrrhetinic acid is an inhibitor of the classical pathway of human complement. Jujube can improve the function of monocytes and phagocytes, enhance muscle strength and weight, promote hemolysin and hemolytic plaque, promote lymphocyte transformation, improve the decomposition of peripheral blood lymphocytes, and promote macrophages to secrete THFα, IL 1 and NO, which has obvious anti-complement activity. Ejiao can promote lymphocyte transformation in healthy people; Increase the phagocytosis percentage and phagocytosis index of macrophages; Can promote NK cells; It can resist the cellular immunosuppression caused by hydrocortisone; At the same time, Ejiao also has the functions of anti-fatigue, anti-radiation and improving cold resistance. Ophiopogon japonicus can enhance the phagocytosis of reticuloendothelial system, antagonize leukopenia caused by cyclophosphamide and 60Co irradiation, increase the production of peripheral leukocytes and serum lysin, improve immune function, enhance the function of pituitary-adrenal cortex system and improve the adaptability of the body. Ramulus Cinnamomi, an adjuvant, has a strong anti-allergic effect. Ginger can change immune function, increase organ index and increase phagocytosis rate of macrophages.

4.8.2 Effects on heart, blood vessels and hemorheology The monarch drug Dihuang has cardiotonic effect, especially on heart failure, and has diuretic and antihypertensive effects. Its antihypertensive effect is related to the increase of cAMP and the decrease of cGMP/cAMP ratio. Ginseng can enhance the release of catecholamine, inhibit the activity of Na+K+ATPase in myocardial cell membrane, and increase Na+Ca2+ exchange, so it has a cardiac glycoside-like effect, which can enhance myocardial contractility, increase cardiac output, increase coronary blood flow, slow down heart rate, and has an antiarrhythmic effect. Ginseng can resist hypoxia and protect myocardium, mainly because it can reduce myocardial oxygen consumption and increase coronary blood flow. Reducing the affinity of hemoglobin for oxygen and releasing more oxygen to tissues is another reason why ginseng can improve the body's hypoxia tolerance. Ginsenoside can reduce the range of myocardial infarction, inhibit the activity of creatine phosphokinase in plasma and reduce the ratio of PGI2/TXA2. Ginsenoside has a dose-dependent inhibitory effect on the conversion of fibrinogen to fibrin induced by plasmin. Panaxadiol saponins can significantly reduce whole blood viscosity and inhibit platelet aggregation; Ginsenosides can inhibit platelet aggregation induced by ADP, thrombin and arachidonic acid by blocking PG metabolism and Ca2+ antagonism. Ginsenosides Rg3 and Rg 1 are the main components that inhibit platelet aggregation, so ginseng has the effect of inhibiting thrombosis. Glycyrrhiza uralensis Fisch has anti-atherosclerosis effect, while glycyrrhizic acid can inhibit phospholipase A2 activity and platelet aggregation. Glycyrrhiza flavonoids have antiarrhythmic effect; Glycyrrhetinic acid can reduce the range of myocardial infarction, and has the effect of angiotensin ⅱa 1 receptor agonist. Ejiao can restore the extremely low level of blood pressure to the normal level, and the effect is lasting; For endotoxic shock, Ejiao can reduce the total resistance of systemic circulation, obviously reduce the relative viscosity of whole blood and plasma, and alleviate or restore the normal microcirculation disorder. Therefore, Ejiao has an anti-shock effect. Ophiopogon japonicus can significantly improve myocardial contractility and cardiac pumping function, increase coronary blood flow and cardiac output, have anti-arrhythmia effect, reverse the inhibition of cardiac function during hemorrhagic shock, improve circulation, raise blood pressure and have anti-shock effect. Ophiopogon japonicus can increase the nutritional blood flow of myocardial infarction, narrow the range of myocardial infarction, and make the myocardial cells that have been obviously damaged (after infarction) quickly repair. The ethanol extract of Fructus Cannabis has the effect of lowering blood pressure and blood lipid. Ramulus Cinnamomi can dilate blood vessels, improve peripheral circulation, increase coronary blood flow, increase nutritional blood flow, improve myocardial function after myocardial ischemia and reperfusion, increase myocardial SOD activity and reduce LPO content. Cinnamaldehyde contained in Ramulus Cinnamomi can inhibit platelet aggregation and has antithrombin effect. Ginger can excite the vascular motor center and heart; Ginger contains 6 gingerol, 8 gingerol and 10 gingerol, which is a cardiotonic drug and can increase myocardial contractility. The effect of ginger on blood pressure can be divided into three stages: transient hypotension, obvious hypertension and persistent hypotension. Ginger can affect AA metabolism in platelets, inhibit the synthesis of TXB2 and PGs, and has anti-platelet aggregation effect.

According to the above two therapeutic mechanisms, this prescription should have therapeutic effect on rheumatic myocarditis, viral myocarditis and arrhythmia.

4.8.3 Effects on nervous and endocrine system functions Rehmannia glutinosa can significantly enhance the hypnotic effect of subthreshold dose of pentobarbital sodium, thus playing a sedative role. Rehmannia glutinosa can resist the decrease of corticosterone concentration caused by dexamethasone and prevent adrenal cortex atrophy; Antagonizing the hypofunction of pituitary-adrenal cortex caused by glucocorticoid; Rehmannia glutinosa can increase the maximum binding capacity of renal β receptor and restore it to normal, and reduce T3 and T4. Ginseng can stimulate pituitary-adrenal cortex system, promote adrenal cortex to secrete corticosteroids, and also stimulate hypothalamus-pituitary-gonad axis, promote the release and synthesis of sex hormones and the development of sexual organs, and promote insulin secretion; Improve the body's stress response ability, promote thyroid function, improve hypoxia tolerance, enhance the body's adaptability, have anti-fatigue, anti-stress, anti-mutation, anti-aging effects, and reduce physiological functions; The pharmacological activity of ginseng is biphasic due to different body States, which is beneficial to the recovery of the body. Ginseng can dilate cerebral vessels, increase cerebral blood flow, improve cerebral oxygen supply and energy metabolism, promote the synthesis of RNA and protein in the brain, promote the development of brain nerve cells, increase brain weight and cerebral cortex thickness, increase the number of synapses in the upper layer of pyramidal cells in CA3 area of hippocampus, and improve the function of hippocampal neurons. Protect nerve cells, reduce the death rate of nerve cells, promote the synthesis and release of neurotransmitter Ach in the brain, and increase the contents of DA and NA in the brain. Therefore, it can promote the learning and memory function of the brain and regulate the excitement and inhibition of the central nervous system. By exciting the cerebral cortex and balancing the processes of excitation and inhibition, the nerve activity can be restored to normal, the flexibility of nerve activity can be improved, and the efficiency of mental work can be improved. The total flavonoids contained in Glycyrrhiza uralensis Fisch has protective effect on cerebral ischemia-reperfusion injury, and glycyrrhizic acid can increase the activities of ATPase and lactate dehydrogenase in brain mitochondria and alleviate brain edema after ischemia-reperfusion. Glycyrrhiza FM 100 has sedative, analgesic and anticonvulsant effects; It can stimulate hypothalamus-pituitary-adrenal cortex axis to produce corticosteroid-like effect and improve the endocrine regulation ability of the body. Jujube has hypnotic and sedative effects, and jujube polysaccharide can reduce brain aging. Ophiopogon japonicus can enhance the function of pituitary-adrenal cortex system and improve the adaptability of the body; At the same time, Maidong decoction also has sedative effect, which has synergistic effect with chlorpromazine and pentobarbital sodium. Ophiopogon japonicus can obviously lower blood sugar. Sagittarius has analgesic effect. Guizhi decoction has antipyretic and analgesic effects as an adjuvant, and cinnamaldehyde has sedative and anticonvulsant effects. Ginger also has the above effects of cassia twig. The excitatory effects of ginseng, Ophiopogon japonicus and Glycyrrhiza uralensis Fisch on pituitary-adrenal cortex system will inevitably increase the secretion of corticosteroids in vivo, thus effectively exerting the functions of anti-inflammatory, antipyretic, promoting substance metabolism and water and salt metabolism, especially the "permission" function of glucocorticoid, which can coordinate the functions of other hormones in vivo and restore the balance in vivo.

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4.8.4 Effects on hematopoiesis and cellular function: Rehmannia glutinosa can accelerate the proliferation and differentiation of erythroid hematopoietic progenitor cells (CFUE) and pluripotent hematopoietic stem cells (CFUS) in bone marrow, and has a significant effect on hematopoiesis; Ginseng can promote the mitosis and hematopoietic function of bone marrow cells by promoting the synthesis of DNA, RNA, protein and fat in bone marrow. Among them, ginsenoside R0 and total ginsenoside can obviously promote bone marrow potential stem cells, mainly in promoting the differentiation of red blood cells and promoting the formation of mixed colonies composed of erythroid, granulose and megakaryoid; At the same time, ginsenoside can promote the secretion of hematopoietic factor GHCSF, hematopoietic related factors IL3 and IL6 by lymphocytes and bone marrow stromal cells. Panaxadiol extract can increase the iron uptake rate of hemolytic rabbits and increase the radioactive iron uptake by the liver of hemorrhagic rabbits. Jujube is rich in vitamins, amino acids, sugars and trace elements, which provides sufficient raw materials for hematopoiesis. Jujube and licorice have certain therapeutic effects on anemia, and their immune promotion and regulation functions are also in the middle of various anemia. Ejiao has a powerful function of enriching blood and generating blood, and its collagen is beneficial to hematopoietic stem cells. Glycosaminoglycan is closely related to cell proliferation and tissue differentiation of hematopoietic system, so it can not only significantly increase hemoglobin, reticulocyte and red blood cell, but also significantly increase the total number of white blood cells and platelets. Glycine contained in Ejiao can promote the absorption of calcium and has the function of positive calcium balance; Ejiao contains muscle components and various amino acids, which can promote the regeneration of muscle cells and form normal muscle fibers.

4.8.5 Antioxidant and anti-aging effects Rehmannia glutinosa can enhance the activity of glutathione peroxidase in blood and reduce the content of lipid peroxide, thus having anti-aging effect. Ginseng contains a variety of antioxidant substances, and can also regulate physiological functions such as nerve, endocrine, immune function and substance metabolism. Ginseng maltol, salicylic acid and vanillic acid all have obvious antioxidant effects, and maltol can also capture free radicals and reduce the exposure of sulfhydryl groups in membrane proteins, thus stabilizing the structure of membrane proteins. Panax ginseng polyacetylene can inhibit lipid peroxidation of microsomes; Ginsenosides in roots, stems and leaves of ginseng can increase the activities of SOD and CAT, and decrease the content of lipid peroxide. Ginsenoside can inhibit the damage of free radicals to vascular endothelial cells and resist the damage of oxygen free radicals to myocardium. Panaxadiol saponins can improve SOD activity and inhibit brain injury caused by cerebral ischemia and reperfusion after ischemia. Ginseng has anti-stress effect, can increase the tolerance to hypoxia, low temperature and high temperature, and has positive effects on heat stress, noise stress and light stress. Ginsenosides in the roots, fruits, stems and leaves of ginseng can promote the proliferation of human embryonic lung fibroblasts in the elderly, transform "undivided" cells into "divided" cells in the aging cell population, and shorten the cell division cycle. Ginsenosides can also promote the synthesis of RNA, DNA and protein, protect the hematopoietic function of bone marrow, increase the number of peripheral blood cells, promote the synthesis of DNA, RNA, protein and fat in bone marrow, promote the mitosis of bone marrow cells, and promote the hematopoietic function of bone marrow. Glycyrrhiza uralensis Fisch has the function of detoxicating various drugs, such as drug poisoning, food poisoning, metabolite poisoning, bacterial toxin and pesticide poisoning. Glycyrrhiza uralensis Fisch has the effects of scavenging free radicals and antioxidation. Jujube polysaccharide, the main component of jujube, can improve the activity of SOD and CAT in blood, reduce the content of LPO in brain, liver and plasma, and scavenge free radicals, especially reactive oxygen species, which is the main component of delaying aging. Jujube is rich in protein, sugars, organic acids, vitamins and trace elements, and also has anti-aging effect. Colla Corii Asini has the functions of anti-radiation, anti-fatigue and improving cold tolerance, while Ophiopogon japonicus has the functions of anti-lipid peroxidation and anti-hypoxia, which has a strong scavenging effect on reactive oxygen free radicals, inhibits monoamine oxidase activity in the brain, improves plasma, liver, SOD activity and total antioxidant capacity, and significantly reduces MDA content. Ramulus Cinnamomi can inhibit histamine production, inhibit PG synthesis and release, inhibit complement activity, scavenge free radicals, and has anti-inflammatory and antioxidant effects. Ginger extract can scavenge superoxide anion and hydroxyl radical, inhibit hemolysis caused by H2O2, and inhibit MDA production and lipid peroxidation in liver. 6. Anti-pathogenic microorganisms and anti-inflammatory effects

Radix Rehmanniae has antibacterial effect on tinea pedis, Microsporum gypseum and other fungi. Glycyrrhiza extract and sodium glycyrrhetate have inhibitory effects on Staphylococcus aureus, Mycobacterium tuberculosis, Helicobacter pylori, Escherichia coli, amoeba and trichomonas. Glycyrrhizic acid compounds exert broad-spectrum antiviral effects, especially on HIV, herpes simplex virus and varicella-zoster virus, by directly acting on various virus particles and indirectly acting on inducing interferon and increasing the activity of NK cells and macrophages. Glycyrrhiza polysaccharide can inhibit herpes simplex virus, vesicular stomatitis virus and vaccinia virus; Glycyrrhizic acid can inhibit adenovirus, coxsackie virus and syncytial virus; Glycyrrhizin can not only inhibit the above virus, but also inhibit hepatitis virus, and monoamine glycyrrhizinate can inhibit HIV. Ophiopogon japonicus saponin, Ophiopogon japonicus decoction and Ophiopogon japonicus powder have inhibitory effects on Staphylococcus albus, Bacillus subtilis, Escherichia coli and typhoid Bacillus. Ramulus Cinnamomi, an adjuvant, not only has a strong inhibitory effect on the above bacteria, but also has a strong inhibitory effect on common skin fungi, as well as anthrax, Vibrio cholerae, Salmonella and Shigella. Cinnamaldehyde has inhibitory effect on mycobacterium tuberculosis, and Guizhi decoction also has inhibitory effect on influenza virus and orphan virus. The water extract of ginger has obvious inhibitory effect on typhoid Bacillus, Vibrio cholerae, Salmonella, Staphylococcus, Streptococcus and Streptococcus pneumoniae. Its alcohol extract also has inhibitory effects on Staphylococcus aureus, Staphylococcus albicans, Pseudomonas aeruginosa and Shigella dysenteriae. At the same time, it also has inhibitory effect on common skin fungi.

4.9 Sing the song of burning licorice soup, ginseng, cinnamon, ginger, jujube wine and hemp seed; Pulse knot leads to palpitation, fatigue, lung atrophy and deficiency of qi and blood. [3]

4. 10 Differentiation and Treatment of Taiyang Disease from Treatise on Febrile Diseases.

5 Origin of Miscellaneous Diseases and Rhinoceros Candle 17 Prescription of Radix Glycyrrhizae Preparata 5. 1 Prescription of Radix Glycyrrhizae Preparata

5.2 is composed of roasted grass, donkey-hide gelatin, Radix Rehmanniae, Radix Ophiopogonis, Ginseng Radix and Fructus Cannabis.

5.3 Roasted Glycyrrhiza Decoction, one of the seventeen prescriptions in The Origin of Miscellaneous Diseases, is mainly used to treat pathogenic qi stagnation caused by heat and dryness.

5.4 Pay attention to Zhong Fang's ginseng, which is called "American ginseng" by Yaobumen.

5.5 sources