What does ca 19-9 stand for?

CA 19-9 is a mucin glycoprotein tumor marker, and it is the most sensitive marker for pancreatic cancer reported so far.

CA 19-9 is a mucin glycoprotein tumor marker, and it is the most sensitive marker for pancreatic cancer reported so far.

background

CA 19-9 is carcinoembryonic antigen, which is expressed by several different cancers, but especially cancer. Together with CEA, this may be a useful marker to determine prediction and tumor recurrence.

Characteristics of clinical occupational description

carcinoma of colon

CA 19-9 is considered as the most important predictor of advanced colorectal cancer.

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Department of Radiotherapy and Oncology, Helsinki University Central Hospital, Finland.

Journal of Surgical Oncology1February 992; 49(2):78-85 Abstract

Response cards and predictors in advanced colorectal cancer, tumor markers such as carcinoembryonic antigen (CEA) and CA 19-9 were analyzed.

Eighty-five patients participated in the phase II chemotherapy study from June 1984 to July 1990. Three drug regimens were implemented, including low-dose epirubicin and continuous methotrexate 5- fluorouracil, followed by leucovorin rescue. Serum samples of CEA and CA 19-9 were obtained at intervals of 4-6 weeks before starting chemotherapy.

In univariate analysis, Karnofsky, the location of main tumor, the degree of metastasis, the occurrence of gastrointestinal or liver metastasis, the levels of CEA(20 μ m /L resection) and CA 19-9 in serum were related to survival.

In the stepwise multidimensional distribution analysis, the increase of CA 19-9 level, bad Karnofsky and the occurrence of liver metastasis are independent harmful predictors. Tumors originating from the left colon have better prediction than other tumors. This is related to the relatively high reaction speed of this patient group. The level of serum CA 19-9 is the most important predictor of whether it is a continuous variable or a binary variable in this model. There is a normal level of CA 19-9 in patients, which is 30.0 months (95% lower confidence interval: 16.4 months; The upper limit cannot be calculated), and the value of dissolving CA 19-9 is 10.3 months (8.0- 12.6 months, 95% confidence interval). 585 patients were in complete remission and 20 patients were in partial remission, with a total remission rate of 29%.

Compared with tumor shrinkage, "CEA reaction" and "CA 19-9 comparative reaction" were 84% and 88%, respectively, and their specific sensitivity was 77% and 67%. In a word, the value of CEA in serum seems to be the best tumor marker for response prediction, although the level of CA 19-9 is one of the best available predictive display cards in advanced colorectal cancer.

The prediction of roughness is related to the elevated serum level of CA 19-9, which is in advanced color cancer, independent DNA ploidy or SPF.

Principal responsible persons: Li, Li.

Department of Radiotherapy and Oncology, Helsinki University Central Hospital, Finland.

Eur J cancer constellation1993; 29a (12):1691-6 Summary

DNA ploidy, S-phase score (SPF) as tumor, carcinoembryonic antigen (CEA), serum CA 19-9 and other tumor markers and main clinical parameters as predictive factors were analyzed. Patients with advanced colorectal cancer 105.

All 105 patients were treated with three drugs, including low-dose epirubicin, continuous methotrexate and 5- fluorouracil, followed by leucovorin rescue. In univariate analysis, sex, Karnofsky index, degree of gastrointestinal metastasis, incidence, CEA and CA 19-9 were related to survival. With the increase of age, liver appearance or lung metastasis, DNA ploidy or SPF have no significant correlation with survival time.

In the stepwise multidimensional distribution analysis of elevated serum CA 19-9 levels, poor Karnofsky index and metastasis of multiple sites are independent harmful predictors. According to multidimensional distribution analysis, patients were divided into three categories. Group 1 included 32 patients with Karnofsky >: Or = 80, who had normal serum CA 19-9 levels and transferred to a unique site. The second group included 48 patients with Karnofsky≥80°, who transferred the ascending clarified liquid at CA 19-9 level or at multiple stations. Group 3 included 14 patients and Karnofsky.

According to these results, we think that the experimental intervention for advanced colorectal cancer should include the determination of serum CA 19-9 level, which is the most important predictor, and other independent predictors.

Significance of CEA, CA 19-9 and CA72-4 in detecting the recurrence of colorectal cancer.

Holubeck Jr., Topolkan, Pikner, Pecan, Vá clav Ikova, Vithova, Molacek, Steber P, holden Riels, LH, and Senator Finek.

Department of Internal Medicine, Department E, Clare University Hospital. Benaise, Bilsen, Czech Republic13,30599.

Royal Society of Anti-cancer Economics 20001February; 20(6D):5237 44 Abstract

According to the retrospective evaluation of routine data of patients with colorectal cancer, the significance of CEA, CA 19-9 and CA72-4 as early detection of disease recurrence was evaluated. They also considered the dependence of these data analysis results in the definition of this group of patients who have no evidence of disease (NED) and reproduce with disease (radar data).

Patients and Methods: Serum CEA, Ca 1 9-9 and CA72-4 levels were measured in 5 17 patients from 1994 to1month to1March 999, and compared with the clinical conditions confirmed by color cancer and patients' retrospective cases.

Results: CEA and CA 19-9 showed considerable sensitivity, while CA72-4 showed lower sensitivity in detecting local recurrence of colorectal cancer. CEA is the preferred marker for detecting distant metastasis, especially liver metastasis, because its sensitivity is much higher than the other two monitored markers.

Conclusion: The use of routine data requires detailed analysis and a clear definition of patients with NED and radar data. From this analysis for data evaluation, the following conclusions can be drawn: a) tumor marker resection value and sensitivity and forgiveness value are 95% specifically related to the measurement definition of patients and NED, which strongly depends on the group and radar data; b) patient group and NED are well depicted, as if no progress has ever occurred, and all values are within a period of more than 6 months suddenly from the end of treatment and continuous advertising method, or before progress, death or final marker evaluation, and excluded groups. C) For the patient profile and radar data preferred by the group, it is suggested that only the value of forgiveness during the first series, after surgery or on-the-job treatment should be considered. D) These conclusions refer not only to the conventional data, but also to the fact that a condition is a reliable evaluation and any research is completed, because they ensure the complete homogeneity and comparability of the results of each group.

Multidimensional distribution analysis of CEA and CA 19-9 predictive values: Serum level is in color cancer.

Wright W, Steber P, Reuters C, nagel D, Liu Werner U, Lammers R. 。

Clinical chemistry, University of Munich, Grosshadern, Klinikum Institute, Germany.

Royal Society of Anti-cancer Economics 20001February; 20(6D):5 195 8 abstract

Carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) are the most commonly used tumor-associated antigens in patient management and color cancer. The purpose of this study is to evaluate the predictive value of CEA and/or CA 19-9 and classical predictors (age, sex, tumor invasion and grade) in 495 patients.

Patients and Methods: This retrospective study was conducted in patients with frozen serum (stored at -70 degrees Celsius) and histologically confirmed colon cancer. The estimate of the survival function is calculated (Kaplan Meyer). Patients were divided into two groups according to preoperative marker levels. The calculation of resection level is used in healthy individuals, and the specificity is 100% year: Or = 4 ng/mL is CEA, Or = 60 U/mL is CA 19-9. The difference between birth curve and storage curve is estimated by using logarithmic permutation test. Multivariate Cox's is a comparative example of risk regression analysis. The level of tumor markers and survival time between administrative review associations. Classical predictors such as age, sex, tumor invasion and tumor stage (Duke classification) were included as covariables. According to the tumor stage, mantelpiece Haenszel method was used to estimate the survival rate of patients with colorectal cancer and high-level tumor-associated antigens.

Results: Duke stage (logarithmic arrangement χ square = 231.9; P < 0.0001) represents the best predictor other than CA 19-9 (logarithmic arrangement χ square = 162.5). CEA showed logarithmic arrangement χ squared 7 1.4. Therefore, CEA and CA 19-9 can be used to distinguish patients with significantly different survival time between the two groups (P

Conclusion: In addition to the predicted value of CA 19-9, duke grade after operation represents the best predictive information. The predictive information was provided by proactive CA 19-9, and the serum level was independently obtained by other factors. The classification of the only duke and the level of CA 19-9 were statistically significant (P