Brief introduction of Wang

Wang (1924.11.30-), a native of Xinghua, Jiangsu Province, is an expert in internal medicine and hematology, and one of the pioneers of thrombosis and hemostasis in China. He is known as "the father of cancer-induced differentiation" and is one of the mainland scholars who may win the Nobel Prize in Physiology or Medicine.

1948 (in 37 years of the Republic of China) graduated from Shanghai Aurora University with a doctorate; 1992 was elected as a foreign academician of the French Academy of Sciences; 1994 was elected as an academician of the China Academy of Engineering; in 201/kloc-0, he was awarded the highest position in the country.

Wang has been engaged in the research and clinical work in the field of hematology in medical internal medicine for a long time, pioneered the induced differentiation treatment of leukemia and tumor, and pioneered the treatment of acute promyelocytic leukemia with domestic all-trans retinoic acid in the world. In his medical career of more than 60 years, he has made great contributions to medical practice and theoretical innovation. Wang successfully realized a new strategy of clinical treatment of leukemia by transforming malignant cells into benign cells, which laid a clinical foundation for the theory of induced differentiation. Established the "Shanghai Plan" for the treatment of acute promyelocytic leukemia, clarified its genetic basis and molecular mechanism, and set a successful example of combining basic and clinical treatment; The clinical application research system of thrombosis and hemostasis in China was established.

Chinese name: Wang.

Nationality: China.

Ethnic group: Han nationality

Place of birth: Xinghua, Jiangsu

Date of birth:1924165438+1October 30th.

Occupation: expert in internal medicine and hematology

Graduate school: Shanghai Aurora University

Main achievements: 20 10 National Highest Science and Technology Award

Masterpiece: Hemorrhagic disease

Character experience

1924 (13th year of the Republic of China)165438+1October 30th, Wang was born in a wealthy family in Shanghai. When he was a child, he lived in a three-story house with a big garden. Father has been educating them to be kind to others, paying special attention to education. Among the eight daughters, except the youngest daughter who was influenced by the Cultural Revolution, the other seven all graduated from famous universities in China, and they have made achievements in their respective fields as adults, and they are all proficient in more than two foreign languages.

1936 (twenty-five years of the Republic of China), Wang graduated from Saposai Primary School (now the first central primary school in Luwan District) run by the French Concession in Shanghai.

1942 (thirty-one years of the Republic of China), Wang went straight to Aurora University to choose a medical major. "On the one hand, this is because after my grandmother died, my father wanted one of my children to become a doctor. On the other hand, the most important thing is that being a doctor can help many people. "

1948 (thirty-seven years of the Republic of China), Wang graduated from the Medical College of Aurora University (now the Medical College of Shanghai Jiaotong University) with a doctor of medicine. Because of his excellent performance, he stayed in Guangci Hospital (the predecessor of Ruijin Hospital) as a resident.

From 65438 to 0952, Wang Yizhi devoted himself to the study of hematological diseases. In the same year, Guangci Hospital was subdivided into four specialties: digestion, cardiovascular, endocrine and hematology. Wang began to engage in hematology research under the guidance of the famous internal medicine expert Kuang An.

65438-0953 Wang has encountered such a situation in clinic: some patients usually have no bleeding symptoms, but they will bleed after minor operations such as tooth extraction. Wang read a lot of literature and learned that the level of coagulation factor in plasma is the key to bleeding, which can't be found by general laboratory examination, so it is necessary to carry out thromboplastin production test. But when doing this test, it is necessary to coat the glass tube wall with silica gel. At that time, there was no such material in China. Wang used paraffin instead of silica gel, and successfully established this detection method for the first time in China, and made a diagnosis, which solved the problem of diagnosis and treatment of this unexplained bleeding. In the same year, Wang signed up for the medical team to resist US aggression and aid Korea. From June+10, 5438, Wang came to the rear hospital of Boli County, Heilongjiang Province for consultation as the attending physician of the internal medicine mobile medical group of Northeast Military Region. There, more than 60 volunteer soldiers collectively developed symptoms such as hemoptysis and headache, and were initially diagnosed as tuberculous meningitis.

Since 1954, Wang Yizhi has been engaged in the research on thrombosis and hemostasis, and has taken the lead in establishing the diagnosis methods of hemophilia A and B and mild hemophilia in China.

1959, the grandiose wind of the Great Leap Forward also affected the hospital, and Wang and his team proposed "three years to conquer leukemia".

From 65438 to 0963, Wang was transferred to the medical French class as a teacher, and Wang, who was proficient in French, began to study French textbooks again.

During 1973, Wang was transferred back to the internal medicine department of Shanghai Ruijin Hospital for treatment and research of blood diseases. Wang only consults domestic and foreign academic literature without making rounds or probing, and at the same time edits or compiles many hematology books.

From 65438 to 0978, acute promyelocytic leukemia (APL) became one of Wang's research hotspots.

From 65438 to 0980, Wang began to study the diagnosis and treatment of cancer.

65438-0982 instructs graduate students to carry out research on immune thrombocytopenia, and then carries out research on the stimulation of heparin on platelets and megakaryocytes.

65438-0997 was invited to co-write the chapter "Changes of Megakaryocytes and Platelets in Immune Thrombocytopenic Purpura" with Zhixiang Shen, which was the first time that China scholars were invited to write papers on hematology in international journals. The first edition 1988, the second edition 1996 and the third edition in 2004 of Thrombosis and Hemostasis, written by Wang, Li Jiazeng, Ruan Changgeng and later by Han and Song Shanjun, became representative monographs in this field in China.

From 65438 to 0982, Wang transferred from a clinician to the Department of Basic Medicine to review basic medical textbooks.

65438-0983 Wang experimented with all-trans retinoic acid, and observed under the microscope that "acute promyelocytic cells" successfully differentiated into normal cells under the action of all-trans retinoic acid. One year later, this differentiation induction effect was confirmed.

65438-0986 Wang treated the first case of acute promyelocytic leukemia with the original all-trans retinoic acid. In the same year, 24 patients with acute promyelocytic leukemia were treated and improved.

From 65438 to 0994, Wang He and his team contributed to a famous academic magazine in China, but they were criticized as "rabble". The other party's reply is that the research units are all grass-roots hospitals, and there are no well-known hospitals, so they will not be published. Wang said, "Science and technology awards should put the truth first, and we can't just look at the papers published in the highest magazines, which have influence among the masses and ignore the innovation of research.

From 65438 to 0996, Wang voluntarily ceded the post of Director of Shanghai Institute of Hematology, which represented the highest level of hematology research in China.

From 65438 to 0997, Wang He was invited to co-write the chapter "Changes of megakaryocytes and platelets in immune thrombocytopenic purpura", which was the first time that China scholars were invited to write papers on hematology in international journals. Thrombosis and Hemostasis, edited by Wang, has become a representative monograph in this field in China, and has been reprinted continuously.

On March 6th, 20 12, Wang He, an academician of China Academy of Engineering, and China Academy of Sciences were awarded the 7th Szentgyorgy Cancer Research Innovation Award by the National Cancer Research Foundation of the United States. This is the highest award for cancer research in the world, and it is also the first time that a scientist outside the United States has won an award.

Major achievements

scientific research

Since 1954, Wang Yizhi has been engaged in the research on thrombosis and hemostasis, and has taken the lead in establishing the diagnosis methods of hemophilia A and B and mild hemophilia in China. The differentiation therapy of cancer was studied from 1980. 1986 is the first in the world to use all-trans retinoic acid to induce differentiation in the treatment of acute promyelocytic leukemia, and has achieved a high remission rate, which provides a successful example for the new theory that malignant tumors can achieve the effect of not damaging normal cells through induced differentiation treatment. Engaged in the research of thrombosis and hemostasis. Firstly, the diagnosis and differential diagnosis methods of hemophilia A and B were established in China, and mild hemophilia was found. According to the theory of induced differentiation, Wang proposed APL induced differentiation therapy on the basis of a large number of experiments, which proved that all-trans retinoic acid could induce malignant promyelocytic leukemia cells to differentiate into benign cells. On the basis of effective remission and treatment of APL, Wang constantly optimized the treatment plan and found that the five-year survival rate can be improved to 95% by combining tretinoin with arsenic oxide. Therefore, APL became the first curable adult leukemia. At the same time of successful clinical treatment, Wang revealed that APL induced by all-trans retinoic acid is a "targeted therapy" method for oncogene molecules.

In the mid-1980s, team Wang cooperated with the Institute of Pharmacology of China Academy of Sciences to isolate four effective components from Pollen Typhae, determine their chemical structures, and clarify their mechanisms of preventing and treating feeding atherosclerosis. In the same period, the research group led by Wang purified von Willebrand factor (vWF) for the first time in China, and established a method for detecting and detecting the antigen and function of hemophilia A carriers, so it won the second prize of scientific research of the Ministry of Health twice. The research team purified and detected anticoagulant proteins (protein C and protein S), β -thromboglobulin and platelet factor 4 for the first time in China, and found and reported protein S deficiency for the first time.

personnel training

Paying attention to the cultivation of young people has always been Wang's insistence. Wang has worked as a teacher in the fields of basic internal medicine, general internal medicine, hematology and pathophysiology, and has trained 265,438 doctors and 34 masters. Among Wang's students, there are famous academicians and couples, and Chen Guoqiang, the youngest chief scientist in "973" and an academician of Chinese Academy of Sciences.

Thesis works

Academician Wang * * * published 3 papers10, edited 5 monographs and participated in the compilation of works 17.

According to the data of China Institute of Science and Technology Information and National Institute of Digital Engineering Technology: 1985, by 2007, Wang had published 136 papers, as follows:

Winning record

Character honor

2065438+July 2009 "The Most Beautiful Struggler" in Shanghai recommended candidates.

social service

He used to be president of Shanghai Second Medical University, director of Shanghai Institute of Hematology, deputy director of Chinese Hematology Society and deputy editor-in-chief of Chinese Journal of Hematology. He is currently a tenured professor at Shanghai Jiao Tong University School of Medicine, a tenured professor at Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, and honorary director of Shanghai Institute of Hematology affiliated to Shanghai Jiao Tong University School of Medicine. He has served as director and attending physician of Ruijin Hospital (formerly Guangci Hospital) affiliated to Shanghai Jiaotong University School of Medicine (1948~ 1960), and deputy director and director of Pathophysiology Teaching and Research Department of Shanghai Jiaotong University School of Medicine (formerly Shanghai Second Medical University) (1960~ 1982).

Anecdotes of characters

From 65438 to 0996, Wang began to learn to use computers and surf the Internet at the age of 72. Since then, he has consulted medical literature online for more than three or four hours every day. Wang recalled that he went to the Chinese medicine museum every weekend to check the information and copied the valuable content word by word, and he could read at most four or five articles a day. He can't help feeling that the current network is so convenient. Wang said to him, "As a teacher, I can't always fool young people with old knowledge. Let them see that my knowledge is constantly improving, and they will be inspired to keep learning. " In fact, every "open-book exam", the most nervous is not the examinee Wang, but the examiner. Young doctors are not only excited about the opportunity to get a true biography of Mr. Wang, but also nervous about all kinds of questions that Mr. Wang may ask.

Personality assessment

As a doctor, you have been rigorous in researching and saving lives for the past 60 years. You have not only done a lot of pioneering work in the clinical and research fields of hematology, but also brought good news to countless patients with superb medical skills and made important contributions to the development of medical undertakings in China. You are willing to be a ladder and respected. You have not only trained a large number of top medical talents, but also set an example for everyone to learn in being a man, a doctor, a teacher and a teacher. You are a contemporary intellectual.

The academic achievements of Professor Wang and Professor Wang fully show that translational medicine research is promising in China. Under the banner of Mr. Wang, after nearly half a century's efforts, four generations of Shanghai Institute of Hematology finally basically conquered acute promyelocytic leukemia and established a new model of tumor cell differentiation treatment. Over the past 60 years, you have devoted yourself wholeheartedly to the cause of medical science, not being tempted by prosperity, not being disturbed by profit, not caring about poverty and not seeking wealth; In the field of leukemia, you creatively put forward the theory of inducing differentiation of tumor cells without damaging normal cells, and pioneered the treatment of acute promyelocytic leukemia with all-trans retinoic acid in the world, which attracted the attention of the world medical community; Over the past 60 years, you have been a doctor, saving the wounded and dying, selfless dedication, treating countless patients with loving and sincere big doctor mind and superb medical skills; Over the past 60 years, you have been teaching and educating people, holding the lamp to lead the way, paving the way for students to grow up intelligently, and cultivating a large number of medical clinical and scientific research talents. You are our teacher and an example of learning, practicing medicine, educating people and cultivating self-cultivation. Your scientific spirit, superb medical skills, morality and personality are examples of our lifelong learning! (Comments by Zhu Chen, Minister of Health of the People's Republic of China)

As a world-famous hematology expert, you have made a series of achievements in the research of thrombosis and hemostasis, and the study of syndrome differentiation and treatment of cancer in the spirit of being scientific and realistic during your academic career of more than 60 years. You pioneered the application of all-trans retinoic acid in the treatment of acute promyelocytic leukemia in the world, which provided a successful example for the new theory that malignant tumors can be treated by induced differentiation without damaging normal cells, laid the clinical foundation for the theory of induced differentiation and formed a new strategy for the clinical treatment of leukemia. You have created a new way for clinical diagnosis, treatment and scientific research of hematology in China, laid the foundation for the development of hematology in China, and laid the international status of hematology in China. Your outstanding academic achievements have attracted worldwide attention, and you have won a series of scientific and technological awards, such as the Kettering Award, the highest award in the field of international oncology. You heal the wounded and rescue the dying, devote yourself to your work, and treat countless patients with your loving and sincere mind and skillful medical skills. You teach and educate people, be a teacher by example, and cultivate and educate a large number of talented people with noble personality and profound knowledge, with peaches and plums all over the world. With the virtue of doctors and the wisdom of scholars, you have made outstanding contributions to the innovation of engineering science and technology, the research of medical education and the development of medical and health undertakings in China. You are a model for the vast number of engineers and technicians and are deeply respected by the broad masses of people. (Zhou Jiping, Dean of China Academy of Engineering)

You are one of the pioneers in the field of thrombosis and hemostasis in China, and your achievements are well-known at home and abroad. You have devoted yourself to saving lives and medical research for decades, made outstanding contributions to the development of hematology and tumor induction and differentiation in China, and trained a large number of top talents in medical clinical and scientific research fields. You have always been indifferent to fame and fortune, conscientious and rigorous in your studies, setting an example for medical workers, scientific and technological workers and educators. We especially need masters like you to cultivate more top-notch innovative talents, so as to promote Shanghai's independent innovation ability and level. (Han Zheng, Deputy Secretary of Shanghai Municipal Committee and Mayor)

Wang is not only a well-respected famous doctor, but also trained a group of excellent hematology professionals for the country. Comrade Wang is an outstanding representative of the national medical and health front, and also an example and model for the majority of medical staff to learn. (Comment by Zhang Mao, Party Secretary of the Ministry of Health)

Academician Wang is "a scientist we admire, a doctor we respect, an educator we admire, and a well-deserved model for learning." Academician Wang is an advocate and practitioner of translational medicine. (Comments by Yin, Director of the Standing Committee of Shanghai Municipal People's Congress and Secretary of the Municipal Party Committee)

Professor Wang is a representative of translational medicine research in the world, one of the pioneers of thrombosis and hemostasis in China, and an outstanding research doctor. He is not only a respected medical expert, but also an outstanding educator. He is a model of scholars and teachers in the fields of medicine and education in China. It is decided to call on the teachers, students and medical workers of the whole school to learn from Professor Wang's noble medical ethics, innovative spirit of being the first, and lofty thought of being a teacher. It is decided that teachers, students and medical staff should follow Professor Wang's example, never forget the historical mission and social responsibility entrusted by the country and the times, and strive to create world-class universities and medical schools, making new and greater contributions to the continuous progress of human science and technology, the great rejuvenation of the country and the nation, and the sustained and rapid development of higher education. (Comment by Ma, Party Secretary of Shanghai Jiaotong University)

Wang Lao is "a selfless and fearless doctor who respects science, a diligent and broad-minded scientist, a teacher who sets an example, a master who is ambitious and indifferent to fame and fortune, and an old man who is diligent in studying and learning endlessly". (Comments by Chen Guoqiang, Vice President of Shanghai Jiaotong University and Dean of Medical College)

Dr. Rainbow Yizhen is respected and revered precisely because they have done things that ordinary people have never done with extraordinary wisdom, perseverance and character. The Institute of Hematology founded by Wang Lao is a model of translational medicine, and Wang Lao himself is a practical model of translational medicine. (Li Hongping, former dean and tenured professor of Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine)

"Teacher Wang is my mentor on the road to medicine, a model in our medical life, and a guide for all my colleagues in the Institute of Hematology! (Comment by Chen Saijuan, academician of China Academy of Engineering and director of Shanghai Institute of Hematology)

We should learn from Wang's enthusiastic attitude of serving patients wholeheartedly, and get rid of impetuous academic spirit, courage and determination to make decisions, and the true nature of a doctor who is indifferent to fame and fortune, modest and calm. (Comments by Chief Physician Zhang, Department of Rheumatology and Immunology, Peking Union Medical College Hospital)

Academician Wang has noble medical ethics, obtained a series of scientific research achievements with international influence, and trained a number of outstanding hematology professionals for the country. (Ministry of Science and Technology of the People's Republic of China)

He is always diligent and earnest, gentle and amiable to patients, and has outstanding academic achievements. However, when signing and awarding prizes, his consistent style always attributes his achievements to the team and pushes collaborators, especially young people, to the front desk. (People's Pictorial Review)

Academician Wang, with his 60-year medical experience and understanding, told his hometown medical staff about his life and knowledge in plain language. (Xinhua Daily Review)

According to insiders, following researcher Tu Youyou of Chinese Academy of Traditional Chinese Medicine 20 15, artemisinin therapy was used to treat malaria, Wang malignant tumor induced differentiation therapy, Zhang Tingdong arsenic therapy was used to treat leukemia, Wang Xuechang curved blade acupuncture was used to treat neck, shoulder, low back and leg pain, Sheng Zhiyong's law of burn course and new therapy, Shi's splicing structure and mechanism, acupuncture analgesia principle and Wu's new theory of liver surgery.