What are the treatments for coronavirus infection?

At present, there are no effective antiviral drugs. The existing antiviral drugs are not only unsatisfactory, but also have great side effects, and most respiratory virus infections are self-limited, so it is of little significance to use the existing antiviral drugs. It is suggested to use ribavirin to treat severe respiratory syncytial virus infection in infants. Ribavirin is a synthetic nucleoside antiviral drug, which can effectively fight against some types of viruses, such as herpes virus, pox virus, influenza virus, parainfluenza virus, rhinovirus, respiratory syncytial virus and enterovirus. Its antiviral mechanism is not clear. Aerosol inhalation is mainly used to treat severe respiratory syncytial virus infection in infants. Inhale 12h every day for 3 days, which can relieve symptoms and shorten the detoxification cycle. Animal experiments can lead to deformity, and pregnant women are prohibited. In addition to general treatment such as bed rest and drinking plenty of water during fever, respiratory virus infection is mainly symptomatic treatment: high fever can be cooled by physical or drug, and patients with severe headache can take compound acetylsalicylic acid (compound aspirin) orally. When bronchiolitis and pneumonia appear shortness of breath, asthma and cyanosis, oxygen inhalation, spasmolysis and expectoration should be given to keep the airway unobstructed, tracheotomy and artificial assisted breathing should be carried out if necessary, and cardiac tonic should be given to those complicated with heart failure. Effective antibacterial drugs should be given in time for secondary bacterial infection.

(2) Prognosis

The prognosis is generally good. Lower respiratory tract infection or secondary bacterial infection is more serious. Infants, the elderly or those with original heart and lung diseases and low immune function have poor prognosis. For SARS patients, most of them are relieved or discharged after comprehensive treatment. A few patients will develop ARDS (less than 20%) and die. The mortality rate of critically ill patients seems to be related to the patient's basic disease. Clinically, it is found that the mortality rate of SARS patients with diabetes, coronary heart disease and other basic diseases is high. Univariate analysis showed that age, male and low absolute neutrophil count at onset were predictors of serious illness and death. In multivariate analysis, it is found that only the elderly (patients over 40 years old are more prone to serious diseases) and low absolute neutrophil count are predictors of poor prognosis.