Are all the 88 constellations in the Milky Way?

The concept of modern astronomical constellations only borrows the name of ancient constellations and divides the sky into 88 different regions (for example, the Andromeda galaxy M3 1 is located in the Andromeda region). Every celestial body in the region may be at a different distance from the earth, but it is too far away for us to distinguish their relative distance with the naked eye.

The celestial bodies outside the Milky Way are too far away from us (as you said, Andromeda galaxy M3 1 2.5 million light years away), and because of our limited resolution, even if we can see this galaxy, we can't tell the stars outside the Milky Way (even if there is a supernova explosion in the galaxy outside the river, the naked eye can only see a little light and can't tell the details), so the stars visible to the naked eye in the 88 constellation can be the farthest stars that are said to be visible to the naked eye.